The Encephalophone is a music prosthetic which uses EEG signal ('brain waves') from paralyzed individuals to play musical instruments hands-free, thus re-enabling musical expression in those who have lost this from neurological injury. In conjunction with DXARTS at U.W., clinical trials are being completed at Swedish Neuroscience Institute under a Creativity Connects grant from the National Endowment for the Arts, which culminating in this unique event. This workshop-style experimental concert featured two quadraplegic artists from the clinical trial - Jeremy Best and Jonathan Sari - improvising with the Encephalophone with an ensemble of professional jazz musicians (Chris Icasiano - drums, Evan Flory-Barnes - bass, Alex Guilbert - piano, Ray Larsen - trumpet). They played original compositions written specifically for the instrumentation of the Encephalophone by composer Allan Loucks. The experimental nature of this performance and its musical and technological challenges made for an historic musical event.